Autologous Fibrin Glue (AFG)

Fibrin Sealant, or fibrin “glue,” is a unique human-derived tissue adhesive that is being utilized with increasing frequency in a variety of surgical cases. Fibrin glue is composed of fibrinogen and coagulation factor XIII and varying amounts of other plasma proteins such as fibronectin and plasminogen. Fibrinogen is a protein that plays a key role in blood clotting.  The second component contains thrombin/calcium choloride. Thrombin (either bovine or human origin) is an enzyme that helps convert fibrinogen to fibrin. When mixed together, these agents mimic the last stages of the clotting cascade to form a fibrin clot.


What is Fibrin Glue?

Autologous Fibrin Glue (AFG) is a biologic product that is produced through centrifugation of the patient’s own blood and mixed with thrombin and calcium chloride for it’s hemostatic and adhesive effects.


Surgical Benefits

  • Reduced bleeding
  • Minimize serous fluid collection – Elimination of drains
  • Improved surgical hemostasis
  • Effective tissue adherence
  • Minimize lymphatic leaks
  • Minimize scarring
  • Improved healing time
  • Decreased pain due to less swelling

This cutting edge technology is being utilized in many specialties including: Orthopedic, Plastics, ENT, OB/GYN, Ophthalmology, Oral, and General surgery. The tissue adhesiveness, elastic property, and tensile strength of fibrin glue or sealant has made it an important adjunct in surgical techniques, hemostasis, colostomy closure, splenic injury repair and cardiopulmonary bypass surgery. Because of it’s unique properties, fibrin glue is also being utilized in face lifts and endoscopic brow lift procedures reducing the recovery time, swelling, bruising, scar formation and discomfort of the patient.
The known contraindications for Fibrin glue include:

  • Sensitivity to bovine thrombin – In our practice, we utilize human derived thrombin. Thus, eliminating the concern over bovine thrombin.

Please notify your physician if you have any of the known contraindications listed above.

Costs: The hospital is billed directly for the use of Fibrin glue services. Under most circumstances, there is no out-of-pocket expense to the patient.